A repressible female-specific lethal genetic system for making transgenic insect strains suitable for a sterile-release program

被引：180

作者：

Heinrich, JC ^{[1
]}

Scott, MJ ^{[1
]}

机构：

[1] Massey Univ, Inst Mol BioSci, Palmerston North, New Zealand

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 15期

关键词：

D O I：

10.1073/pnas.140142697

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have developed a tetracycline-repressible female-specific lethal genetic system in the vinegar fly Drosophila melanogaster, One component of the system is the tetracycline-controlled transactivator gene under the control of the fat body and female-specific transcription enhancer from the yolk protein 1 gene. The other component consists of the proapoptotic gene hid under the control of a tetracycline-responsive element. Males and females of a strain carrying both components are viable on medium supplemented with tetracycline, but only males survive on normal medium. A strain with such properties would be ideal for a sterile-insect release program, which is most effective when only males are released in the field.

引用

页码：8229 / 8232

页数：4

共 39 条

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