NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

被引：1455

作者：

Tschopp, Jurg ^{[1
]}

Schroder, Kate ^{[1
,2
]}

机构：

[1] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland

[2] Monash Univ, Monash Inst Med Res, Melbourne, Vic 3004, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 03期

基金：

英国医学研究理事会; 瑞士国家科学基金会;

关键词：

NOD-LIKE RECEPTORS; NALP3; INFLAMMASOME; P2X(7) RECEPTOR; CASPASE-1; RELEASE; ATP; IL-1-BETA; CRYSTALS; DEFENSE; SILICA;

D O I：

10.1038/nri2725

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that activates caspase 1, leading to the processing and secretion of the pro-inflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-18. The NLRP3 inflammasome is activated by a wide range of danger signals that derive not only from microorganisms but also from metabolic dysregulation. It is unclear how these highly varied stress signals can be detected by a single inflammasome. In this Opinion article, we review the different signalling pathways that have been proposed to engage the NLRP3 inflammasome and suggest a model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS).

引用

页码：210 / 215

页数：6

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