Prucalopride for constipation

被引：34

作者：

Camilleri, Michael ^{[1
]}

Deiteren, Annemie ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, CENTER, Rochester, MN 55905 USA

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2010年 / 11卷 / 03期

关键词：

5-HT4; receptor; efficacy; enterokinetic; pharmacodynamics; pharmacokinetics; prokinetic; R093887; R108512; safety; serotonin agonist; PLACEBO-CONTROLLED TRIAL; 5-HT4 RECEPTOR AGONISTS; ENTEROKINETIC AGENT; DOUBLE-BLIND; IN-VITRO; COLONIC TRANSIT; GASTROINTESTINAL TRANSIT; CHOLINERGIC NERVES; ANORECTAL FUNCTION; POTASSIUM CHANNEL;

D O I：

10.1517/14656560903567057

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Importance of the field: Chronic constipation has a high prevalence, and current medical and pharmacological therapies do not restore normal bowel function in all patients. Areas covered in the review: A PubMed search (1965 - 2009) using the following terms alone or in combination: prucalopride, 5-HT4, R093877, safety, toxicity, pharmacokinetics, pharmacodynamics, transit, cardiac, hERG, arrhythmia, potassium current, elderly. What the reader will gain: Understanding of the mechanisms of action, safety, efficacy and indications for prucalopride in patients with chronic constipation. Take home message: Prucalopride is an efficacious and generally safe, new therapeutic option in the management of chronic constipation.

引用

页码：451 / 461

页数：11

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