Application of modelling techniques for the improvement of industrial bioprocesses

被引：31

作者：

Brass, JM ^{[1
]}

Hoeks, FWJMM

Rohner, M

机构：

[1] LONZA AG, Biotechnol Res & Dev Grp, CH-3930 Visp, Switzerland

[2] LONZA Biotec sro, Biotechnol Prod, CZ-28161 Kourim, Czech Republic

来源：

JOURNAL OF BIOTECHNOLOGY | 1997年 / 59卷 / 1-2期

关键词：

modeling; biotransformation; industrial bioprocesses; L-carnitine; 5-methyl-2-pyrazine carboxylic acid; 6-hydroxynicotinic acid; nicotinamide;

D O I：

10.1016/S0168-1656(97)00165-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The impact of modelling on implementation and improvement of four industrial bioprocesses will be reviewed. In one case, (R)-3-hydroxy-4-(trimethylammonio)-butanoate (L-carnitine) production, modelling facilitated finding the most cost-effective fermentation mode. In two other cases, 6-hydroxynicotinic acid and 5-methyl-2-pyrazincarbonic acid production, modelling helped to develop and practise adequate process control systems. In still another process, nicotinamide production, a combination of modelling with process simulation resulted in a drastic reduction of time and cost for process development and also helped to choose the most cost-effective process design. (C) 1997 Elsevier Science B.V.

引用

页码：63 / 72

页数：10

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