Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain

被引：41

作者：

Takayasu, Yuko

Nakaki, Junko

Kawasaki, Toshiyuki

Koda, Ken

Ago, Yukio

Baba, Akemichi

Matsuda, Toshio

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Mol Neuropharmacol, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2007年 / 103卷 / 04期

关键词：

edaravone; permeability transition pore (PTP); reactive oxygen species (ROS); MCI-186; LIVER;

D O I：

10.1254/jphs.SC0070014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Edaravone, a radical scavenger, prevents ischemia/reperfusion injury in the brain, but the detailed mechanism is not known. This study examines the effect of edaravone on mitochondrial permeability transition pore (PTP) in rat brain. Edaravone at 10 - 100 mu M inhibited Ca2+- and H2O2-induced swelling of mitochondria isolated from rat brain. Addition of Ca2+ generated reactive oxygen species (ROS) in isolated mitochondria. Edaravone (10 - 1 00 mu M) inhibited Ca2+-induced generation of ROS. These results suggest that edaravone inhibits opening of mitochondrial PTP in the brain, and they imply that inhibition of mitochondrial PTP may account for the neuroprotective effect of edaravone.

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收藏

页码：434 / 437

页数：4

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