The analysis and crystallographic characterization of 20-hydroxyecdysone

被引：10

作者：

Báthori, M

Kálmán, A

Argay, G

Kalász, H

机构：

[1] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, H-1445 Budapest, Hungary

[2] Univ Szeged, Dept Pharmacognosy, Szeged, Hungary

[3] Hungarian Acad Sci, Inst Chem, Chem Res Ctr, Budapest, Hungary

来源：

CURRENT MEDICINAL CHEMISTRY | 2000年 / 7卷 / 12期

关键词：

D O I：

10.2174/0929867003374165

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

20-Hydroxyecdysone (20E) is an insect molting hormone that is also widely spread in various plants. Many chromatographic methods can be used to identify and/or determine 20E content in samples of biological origin and various spectroscopic methods serve to identify its structural elements. We have utilized X-ray crystallography to reveal the stereostructures of 20E. Our data demonstrates that 20E exists in two different crystalline forms that are both orthorhombic modifications. One form is home-molecular, with a limited freedom of internal rotation of the side chain around the C23-C24 bond and the other, which is a clathrate formed with methanol and water, which minimize the conformational freedom of the side chain.

引用

页码：1305 / 1312

页数：8

共 15 条

[1]

Purification and characterization of plant ecdysteroids of Silene species [J].