Chlamydia pneumoniae infection in patients with cystic fibrosis

被引:21
作者
Emre, U
Bernius, M
Roblin, PM
Gaerlan, PF
Summersgill, JT
Steiner, P
Schachter, J
Hammerschlag, MR
机构
[1] SUNY HLTH SCI CTR,CHILDRENS MED CTR BROOKLYN,BROOKLYN,NY 11203
[2] UNIV LOUISVILLE,SCH MED,LOUISVILLE,KY 40292
[3] ST VINCENT HOSP & MED CTR,CYST FIBROSIS CTR,NEW YORK,NY
[4] UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143
关键词
D O I
10.1093/clinids/22.5.819
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The prevalence of atypical community-acquired infections as acute pulmonary exacerbations in patients with cystic fibrosis was prospectively studied, Thirty-two patients admitted to the hospital because of acute pulmonary exacerbations and 24 clinically stable patients seen for their routine visits were examined, The prevalence of infection with Chlamydia pneumoniae was assessed by culture and serology, and the presence of IgE to C. pneumoniae was studied by immunoblotting, A subgroup of patients was also examined for the presence of Mycoplasma pneumoniae infection, C. pneumoniae was isolated from four patients presenting with acute pulmonary exacerbations (12.5%) and from none of the stable patients; all patients for whom cultures were positive also had IgE to C. pneumoniae, Polymerase chain reaction analysis for M. pneumoniae was not positive for any patient, and only one patient with an acute exacerbation had an antibody titer compatible with a recent infection, We conclude that infection with C. pneumoniae is associated with acute pulmonary exacerbations in some patients with cystic fibrosis and that it may trigger the production of IgE specific to C. pneumoniae, thus leading to bronchial reactivity in these patients.
引用
收藏
页码:819 / 823
页数:5
相关论文
共 18 条
  • [1] ARMITAGE P, 1971, STATISTICAL METHODS, P207
  • [2] MYCOPLASMA-PNEUMONIAE AND CHLAMYDIA-PNEUMONIAE IN PEDIATRIC COMMUNITY-ACQUIRED PNEUMONIA - COMPARATIVE EFFICACY AND SAFETY OF CLARITHROMYCIN VS ERYTHROMYCIN ETHYLSUCCINATE
    BLOCK, S
    HEDRICK, J
    HAMMERSCHLAG, MR
    CASSELL, GH
    CRAFT, JC
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1995, 14 (06) : 471 - 477
  • [3] BRASFIELD D, 1979, PEDIATRICS, V63, P24
  • [4] RAPID, SENSITIVE DETECTION OF MYCOPLASMA-PNEUMONIAE IN SIMULATED CLINICAL SPECIMENS BY DNA AMPLIFICATION
    BUCK, GE
    OHARA, LC
    SOMMERSGILL, JT
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (12) : 3280 - 3283
  • [5] INFECTION WITH CHLAMYDIA-PNEUMONIAE IN BROOKLYN
    CHIRGWIN, K
    ROBLIN, PM
    GELLING, M
    HAMMERSCHLAG, MR
    SCHACHTER, J
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (04) : 757 - 761
  • [6] AIRWAY HYPERREACTIVITY IN CYSTIC-FIBROSIS - CLINICAL CORRELATES AND POSSIBLE EFFECTS ON THE COURSE OF THE DISEASE
    EGGLESTON, PA
    ROSENSTEIN, BJ
    STACKHOUSE, CM
    ALEXANDER, MF
    [J]. CHEST, 1988, 94 (02) : 360 - 365
  • [7] EVALUATION OF SEROLOGICAL METHODS IN THE DIAGNOSIS OF CHLAMYDIA-PNEUMONIAE PNEUMONIA DURING AN EPIDEMIC IN FINLAND
    EKMAN, MR
    LEINONEN, M
    SYRJALA, H
    LINNANMAKI, E
    KUJALA, P
    SAIKKU, P
    [J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1993, 12 (10) : 756 - 760
  • [8] DETECTION OF ANTI-CHLAMYDIA PNEUMONIAE IGE IN CHILDREN WITH REACTIVE AIRWAY DISEASE
    EMRE, U
    SOKOLOVSKAYA, N
    ROBLIN, PM
    SCHACHTER, J
    HAMMERSCHLAG, MR
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (01) : 265 - 267
  • [9] THE ASSOCIATION OF CHLAMYDIA-PNEUMONIAE INFECTION AND REACTIVE AIRWAY DISEASE IN CHILDREN
    EMRE, U
    ROBLIN, RM
    GELLING, M
    DUMORNAY, W
    RAO, M
    HAMMERSCHLAG, MR
    SCHACHTER, J
    [J]. ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE, 1994, 148 (07): : 727 - 732
  • [10] PERSISTENT INFECTION WITH CHLAMYDIA-PNEUMONIAE FOLLOWING ACUTE RESPIRATORY ILLNESS
    HAMMERSCHLAG, MR
    CHIRGWIN, K
    ROBLIN, PM
    GELLING, M
    DUMORNAY, W
    MANDEL, L
    SMITH, P
    SCHACHTER, J
    [J]. CLINICAL INFECTIOUS DISEASES, 1992, 14 (01) : 178 - 182