Immune reaction and colorectal cancer: Friends or foes?

被引：31

作者：

Formica, Vincenzo ^{[1
]}

Cereda, Vittore ^{[1
]}

Nardecchia, Antonella ^{[1
]}

Tesauro, Manfredi ^{[2
]}

Roselli, Mario ^{[1
]}

机构：

[1] Tor Vergata Univ Hosp, Med Oncol Unit, I-00133 Rome, Italy

[2] Tor Vergata Univ Hosp, Dept Internal Med, I-00133 Rome, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 35期

关键词：

Colitis-associated colorectal cancer; Antitumor immunity; Innate immunity; Adaptive immunity; TUMOR-INFILTRATING LYMPHOCYTES; REGULATORY T-CELLS; INFLAMMATORY-BOWEL-DISEASE; INTESTINAL INFLAMMATION; PROGNOSTIC-FACTOR; COLON TUMORIGENESIS; ULCERATIVE-COLITIS; SUPPRESSOR-CELLS; INNATE IMMUNITY; GROWTH-FACTOR;

D O I：

10.3748/wjg.v20.i35.12407

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The potential clinical impact of enhancing antitumor immunity is increasingly recognized in oncology therapeutics for solid tumors. Colorectal cancer is one of the most studied neoplasms for the tumor-host immunity relationship. Although immune cell populations involved in such a relationship and their prognostic role in colorectal cancer development have clearly been identified, still no approved therapies based on host immunity intensification have so far been introduced in clinical practice. Moreover, a recognized risk in enhancing immune reaction for colitis-associated colorectal cancer development has limited the emphasis of this approach. The aim of the present review is to discuss immune components involved in the host immune reaction against colorectal cancer and analyze the fine balance between pro-tumoral and anti-tumoral effect of immunity in this model of disease. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：12407 / 12419

页数：13

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