Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors

被引：348

作者：

Andrejeva, Gabriela ^{[1
,2
]}

Rathmell, Jeffrey C. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Vanderbilt Ctr Immunobiol, Dept Pathol Microbiol & Immunol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Dept Canc Biol, Nashville, TN 37232 USA

来源：

CELL METABOLISM | 2017年 / 26卷 / 01期

基金：

美国国家卫生研究院;

关键词：

FATTY-ACID OXIDATION; HYPOXIA-INDUCIBLE FACTORS; T-CELL-ACTIVATION; REGULATORY T; C-MYC; DE-NOVO; AEROBIC GLYCOLYSIS; PROTEIN-KINASE; FACTOR; 1-ALPHA; LACTIC-ACID;

D O I：

10.1016/j.cmet.2017.06.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from resting tissues. More recently understood is that this metabolic phenotype is not unique to cancer cells but instead reflects characteristics of proliferating cells. Similar metabolic transitions also occur in the immune system as cells transition from resting state to stimulated effectors. A key finding in immune metabolism is that the metabolic programs of different cell subsets are distinctly associated with immunological function. Further, interruption of those metabolic pathways can shift immune cell fate to modulate immunity. These studies have identified numerous metabolic similarities between cancer and immune cells but also critical differences that may be exploited and that affect treatment of cancer and immunological diseases.

引用

页码：49 / 70

页数：22

共 306 条

[1]

A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis [J].