Immunization against the agent of human granulocytic ehrlichiosis in a murine model

被引：65

作者：

Sun, W

Ijdo, JW

Telford, SR

Hodzic, E

Zhang, Y

Barthold, SW

Fikrig, E

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Rheumatol Sect,Clin Invest Lab 610, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Comparat Med Sect, New Haven, CT 06520 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Trop Publ Hlth, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1997年 / 100卷 / 12期

关键词：

vaccine; Ehrlichia; antibody; ticks; intracellular pathogen;

D O I：

10.1172/JCI119855

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The agent of human granulocytic ehrlichiosis (HGE) is a newly recognized tick-borne pathogen that resides within polymorphonuclear leukocytes. C3H/HeN mice can become infected with the agent of HGE (designated aoHGE) by syringe inoculation or tick-borne infection and develop transient neutropenia, They thereby partially mimic human disease and provide a model in which to study immunity to this microorganism. Mice vaccinated with lysates of purified aoHGE, or administered aoHGE antisera, were partially protected from both syringe-and tick-transmitted challenge with aoHGE. These data suggest that antibodies are sufficient to provide substantial, but not complete, immunity against aoHGE.

引用

页码：3014 / 3018

页数：5

共 27 条

[1] A recombinant minigene vaccine containing a nonameric cytotoxic-T-lymphocyte epitope confers limited protection against Listeria monocytogenes infection [J].