The role of cationic antimicrobial peptides in innate host defences

被引：1084

作者：

Hancock, REW

Diamond, G

机构：

[1] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada

[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Anat Cell Biol & Injury Sci, Newark, NJ 07103 USA

来源：

TRENDS IN MICROBIOLOGY | 2000年 / 8卷 / 09期

关键词：

D O I：

10.1016/S0966-842X(00)01823-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cationic antimicrobial peptides are found in all living species. A single animal can contain >24 different antimicrobial peptides, which fall into four structural classes. These peptides are produced in large quantities at sites of infection and/or inflammation and can have broadspectrum antibacterial, antifungal, antiviral, antiprotozoan and antisepsis properties. In addition, they interact directly with host cells to modulate the inflammatory process and innate defences.

引用

页码：402 / 410

页数：9

共 54 条

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