Effect of 17-β-estradiol and ginsenoside Rg1 on reactive microglia induced by β-amyloid peptides

被引：19

作者：

Gong, YS

Zhang, JT ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[2] Beijing Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 1999年 / 1卷 / 03期

关键词：

Alzheimer's disease; microglia; 17-beta-estradiol; ginsenoside Rg(1); superoxide anion; nitric oxide; inflammation; beta-amyloid; IFN-gamma;

D O I：

10.1080/10286029908039859

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The reactive microglias induced by 25 mu mol of beta -amyloid peptides (A beta 25-35) and/or IFN-gamma can initiate the microglial respiratory burst and release NO, respectively. Oxidative stress and inflammatory function have been implicated in Alzheimer's disease (AD). We showed that 10 mu mol 17-beta -estradiol (E-2) and 1-10 mu mol ginsenoside Rg(1) (Rg(1)) could prevent the toxicity of A beta 25-35 and/or IFN-gamma to microglias, inhibit the microglial respiratory burst activity and decrease the accumulation of NO. These results demonstrated the protectional effect of E-2 or Rg(1) on neuron from damaging by reactive microglias in AD.

引用

页码：153 / 161

页数：9

共 21 条

[1] Neuroprotection against oxidative stress by estrogens: Structure-activity relationship [J].