Prevention and management of mucositis in patients with cancer

被引：35

作者：

Herrstedt, J ^{[1
]}

机构：

[1] Copenhagen Univ Hosp, Dept Oncol 54 B1, DK-2730 Herlev, Denmark

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2000年 / 16卷 / 02期

关键词：

mucositis; chemotherapy; radiotherapy; thalidomide; melatonin; amifostine;

D O I：

10.1016/S0924-8579(00)00232-6

中图分类号：

R51 [传染病];

学科分类号：

100401 [流行病与卫生统计学];

摘要：

This review summarises the large number of locally and systemically applied preventive and therapeutic interventions of mucositis in patients with cancer. The need for further elucidation of the pathophysiology and for optimisation of trial methodology is emphasised. Data from trials in animal models and preliminary data in patients indicate that cytokines such as interleukin-1, interleukin-11, TGF-beta3 and keratinocyte growth factor could reduce the incidence of mucositis. Other potentially useful agents are the angiogenesis-inhibiting drug thalidomide, the cytoprotector amifostine and the pineal hormone melatonin. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

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收藏

页码：161 / 163

页数：3

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