Large-scale search of SNPs for type 2 DM susceptibility genes in a Japanese population

被引：32

作者：

Daimon, M

Ji, GJ

Saitoh, T

Oizumi, T

Tominaga, M

Nakamura, T

Ishii, K

Matsuura, T

Inageda, K

Matsumine, H

Kido, T

Htay, L

Kamatani, N

Muramatsu, M

Kato, T

机构：

[1] Yamagata Univ, Sch Med, Dept Internal Med 3, Yamagata 9909585, Japan

[2] HuBit Genomix Inc, Tokyo 1020092, Japan

[3] Yamagata Univ, Sch Med, Dept Lab Med, Yamagata 9908585, Japan

[4] Tokyo Womens Med Univ, Div Stat Genet, Tokyo 1620054, Japan

[5] Tokyo Med & Dent Univ, Med Res Inst, Dept Mol Epidemiol, Tokyo 1010062, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 302卷 / 04期

关键词：

nested case-control study; adjusted for TG and BMI; no stratification; hepatocyte growth factor receptor;

D O I：

10.1016/S0006-291X(03)00248-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The etiology of type 2 diabetes (DM) is polygenic. We investigated here genes and polymorphisms that associate with DM in the Japanese population. Single-nucleotide polymorphisms (SNPs) of 398 derived from 120 candidate genes were examined for association with DM in a population-based case-control study. The study group consisted of 148 cases and 227 controls recruited from Funagata, Japan. No evident subpopulation structure was detected for the tested population. The association tests were conducted with standard allele positivity tables (chi(2) tests) between SNP genotype frequency and case-control status. The independent association of the SNPs from serum triglyceride levels and body mass index was examined by multiple logistic regression analysis. A value of P < 0.01 was accepted as statistically significant. Six genes (met proto-oncogene, ATP-binding cassette transporter A1, fatty acid binding protein 2, LDL receptor defect C complementing, aldolase B, and sulfonylurea receptor) were shown to be associated with DM. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：751 / 758

页数：8

共 30 条

[1] The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].

Altshuler, D ;

Hirschhorn, JN ;

Klannemark, M ;

Lindgren, CM ;

Vohl, MC ;

Nemesh, J ;

Lane, CR ;

Schaffner, SF ;

Bolk, S ;

Brewer, C ;

Tuomi, T ;

Gaudet, D ;

Hudson, TJ ;

Daly, M ;

Groop, L ;

Lander, ES .

NATURE GENETICS, 2000, 26 (01) :76-80

[2] DIABETES IN IDENTICAL-TWINS - A STUDY OF 200 PAIRS [J].

BARNETT, AH ;

EFF, C ;

LESLIE, RDG ;

PYKE, DA .

DIABETOLOGIA, 1981, 20 (02) :87-93

[3] GENE FOR NON-INSULIN-DEPENDENT DIABETES-MELLITUS (MATURITY-ONSET DIABETES OF THE YOUNG SUBTYPE) IS LINKED TO DNA POLYMORPHISM ON HUMAN CHROMOSOME-20Q [J].

BELL, GI ;

XIANG, KS ;

NEWMAN, MV ;

WU, SH ;

WRIGHT, LG ;

FAJANS, SS ;

SPIELMAN, RS ;

COX, NJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1484-1488

[4] Increased c-met expression during ductal β cell neogenesis in experimental autoimmune diabetes [J].

Bulotta, A ;

Di Cesare, E ;

Ponte, E ;

Falchi, M ;

Sciacchitano, S ;

Cucinotta, D ;

Taruscio, D ;

Di Mario, U ;

Anastasi, E .

GROWTH FACTORS, 2001, 19 (04) :259-267

[5] A MISSENSE MUTATION IN THE GLUCAGON RECEPTOR GENE IS ASSOCIATED WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].

HAGER, J ;

HANSEN, L ;

VAISSE, C ;

VIONNET, N ;

PHILIPPI, A ;

POLLER, W ;

VELHO, G ;

CARCASSI, C ;

CONTU, L ;

JULIER, C ;

CAMBIEN, F ;

PASSA, P ;

LATHROP, M ;

KINDSVOGEL, W ;

DEMENAIS, F ;

NISHIMURA, E ;

FROGUEL, P .

NATURE GENETICS, 1995, 9 (03) :299-304

[6] Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR):: a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians [J].

Hani, EH ;

Boutin, P ;

Durand, E ;

Inoue, H ;

Permutt, MA ;

Velho, G ;

Froguel, P .

DIABETOLOGIA, 1998, 41 (12) :1511-1515

[7] A genome-wide search for human non-insulin dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 [J].

Hanis, CL ;

Boerwinkle, E ;

Chakraborty, R ;

Ellsworth, DL ;

Concannon, P ;

Stirling, B ;

Morrison, VA ;

Wapelhorst, B ;

Spielman, RS ;

GogolinEwens, KJ ;

Shephard, JM ;

Williams, SR ;

Risch, N ;

Hinds, D ;

Iwasaki, N ;

Ogata, M ;

Omori, Y ;

Petzold, C ;

Rietzsch, H ;

Schroder, HE ;

Schulze, J ;

Cox, NJ ;

Menzel, S ;

Boriraj, VV ;

Chen, X ;

Lim, LR ;

Lindner, T ;

Mereu, LE ;

Wang, YQ ;

Xiang, K ;

Yamagata, K ;

Yang, Y ;

Bell, GI .

NATURE GENETICS, 1996, 13 (02) :161-166

[8] Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population [J].

Hara, K ;

Boutin, P ;

Mori, Y ;

Tobe, K ;

Dina, C ;

Yasuda, K ;

Yamauchi, T ;

Otabe, S ;

Okada, T ;

Eto, K ;

Kadowaki, H ;

Hagura, R ;

Akanuma, Y ;

Yazaki, Y ;

Nagai, R ;

Taniyama, M ;

Matsubara, K ;

Yoda, M ;

Nakano, Y ;

Kimura, S ;

Tomita, M ;

Kimura, S ;

Ito, C ;

Froguel, P ;

Kadowaki, T .

DIABETES, 2002, 51 (02) :536-540

[9] Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus [J].

Horikawa, Y ;

Oda, N ;

Cox, NJ ;

Li, XQ ;

Orho-Melander, M ;

Hara, M ;

Hinokio, Y ;

Lindner, TH ;

Mashima, H ;

Schwarz, PEH ;

del Bosque-Plata, L ;

Horikawa, Y ;

Oda, Y ;

Yoshiuchi, I ;

Colilla, S ;

Polonsky, KS ;

Wei, S ;

Concannon, P ;

Iwasaki, N ;

Schulze, T ;

Baier, LJ ;

Bogardus, C ;

Groop, L ;

Boerwinkle, E ;

Hanis, CL ;

Bell, GI .

NATURE GENETICS, 2000, 26 (02) :163-175

[10] Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians [J].

Inoue, H ;

Ferrer, J ;

Welling, CM ;

Elbein, SC ;

Hoffman, M ;

Mayorga, R ;

WarrenPerry, M ;

Zhang, Y ;

Millns, H ;

Turner, R ;

Province, M ;

Bryan, J ;

Permutt, MA ;

AguilarBryan, L .

DIABETES, 1996, 45 (06) :825-831

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