A1C and Diabetes Diagnosis: The Rancho Bernardo Study

被引：126

作者：

Kramer, Caroline K. ^{[1
,2
]}

Araneta, Maria Rosario G. ^{[1
]}

Barrett-Connor, Elizabeth ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Epidemiol, Dept Family & Prevent Med, La Jolla, CA 92093 USA

[2] Univ Fed Rio Grande do Sul, Div Endocrinol, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil

来源：

DIABETES CARE | 2010年 / 33卷 / 01期

基金：

美国国家卫生研究院;

关键词：

RETINOPATHY; US;

D O I：

10.2337/dc09-1366

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - To examine the sensitivity and specificity of A1C as a diagnostic Lest for type 2 diabetes in older adults. RESEARCH DESIGN AND METHODS - Cross-sectional study of community-dwelling adults without known diabetes who had an oral glucose tolerance test and A I C measured on the same day. RESULTS - Mean age of the 2,107 participants was 69.4 +/- 11.1 years; 43% were men. Based on the American Diabetes Association (ADA) criteria, 198 had previously undiagnosed type 2 diabetes. The sensitivity/specificity of A1C cut point of 6.5% was 44/79%. Results were similar in age- and sex-stratified analyses. Given the A1C cut point of 6.5%, 85% of participants were classified as nondiabetic by ADA criteria. CONCLUSIONS - The limited sensitivity of the A1C test may result in delayed diagnosis of type 2 diabetes, while the strict use of ADA criteria may fail to identify a high proportion of individuals with diabetes by A1C >= 6.5% or retinopathy.

引用

页码：101 / 103

页数：3

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