Inhibition of HIV-1 reverse transcriptase and HIV-1 integrase and antiviral activity of Korean seaweed extracts

被引：28

作者：

Ahn, MJ

Yoon, KD

Kim, CY

Min, SY

Kim, YU

Kim, HJ

Kim, JH

Shin, CG

Lee, CK

Kim, TG

Kim, SH

Huh, H

Kim, J ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Sungkyunkwan Univ, Dept Biol Sci, Suwon 440746, South Korea

[3] Chung Ang Univ, Dept Biotechnol, Anseong 456756, Kyungki Do, South Korea

[4] Korea Res Inst Chem Technol, Taejon 305600, South Korea

[5] Korea Food & Drug Adm, Natl Inst Toxicol Res, Seoul 122020, South Korea

来源：

JOURNAL OF APPLIED PHYCOLOGY | 2002年 / 14卷 / 05期

关键词：

antiviral activity; HIV-1; integrase; HIV-1 reverse transcriptase; macroalgae; seaweed extracts;

D O I：

10.1023/A:1022192329471

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Forty-seven species of marine macroalgae from the coast of Korea have been screened for the presence of inhibitory compounds against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and HIV-1 integrase (IN). One of 4 Chlorophyta, 8 of 17 Phaeophyta and 6 of 26 Rhodophyta showed inhibitory activity against HIV-1 reverse transcriptase. Five species (Ecklonia cava, Ishige okamurae, Sargassum confusum, Sargassum hemiphyllum, Sargassum ringgoldianum) belonging to Phaeophyta showed to inhibit the 3'-processing activity of HIV-1 integrase. In cell-based assays, the methanol extracts of Bossiella sp. and Chondria crassicaulis inhibited cytopathogenecity of HIV-1 at a concentration below that cytotoxic for MT4 cells.

引用

页码：325 / 329

页数：5

共 11 条

[1] Retroviral integrase, putting the pieces together [J].