Central nervous system relapse in acute promyelocytic leukaemia in patients treated with all-trans retinoic acid

被引：39

作者：

Evans, G

Grimwade, D

Prentice, HG

Simpson, N

机构：

[1] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND

[2] IPSWICH HOSP,DEPT HAEMATOL,IPSWICH,SUFFOLK,ENGLAND

[3] ROYAL FREE HOSP,DEPT HAEMATOL,LONDON NW3 2QG,ENGLAND

[4] UNIV LONDON SCH MED,LONDON,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 98卷 / 02期

关键词：

APL; ATRA; extramedullary relapse;

D O I：

10.1046/j.1365-2141.1997.2333050.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

All-trans retinoic acid (ATRA) is currently recommended as standard treatment for acute promyelocytic leukaemia (APL). However, there has been increasing concern that ATRA is associated with unusual sites of relapse. We present three cases of APL previously treated with ATRA who ultimately relapsed within the central nervous system (CNS) and hypothesize that, by up-regulating intercellular adhesion molecules, ATRA may facilitate the passage of malignant promyelocytes across the blood-brain barrier.

引用

页码：437 / 439

页数：3

共 13 条

[1] A CYTOLOGICAL AND HISTOLOGICAL STUDY OF ACUTE PREMYELOCYTIC LEUKAEMIA
BERNARD, J
LASNERET, J
CHOME, J
LEVY, JP
BOIRON, M
[J]. JOURNAL OF CLINICAL PATHOLOGY, 1963, 16 (04) : 319 - &
[2] EFFECTS OF GRANULOCYTE-MONOCYTE COLONY-STIMULATING FACTOR (GM-CSF) ON EXPRESSION OF ADHESION MOLECULES AND PRODUCTION OF CYTOKINES IN BLOOD MONOCYTES AND OVARIAN CANCER-ASSOCIATED MACROPHAGES
BERNASCONI, S
MATTEUCCI, C
SIRONI, M
CONNI, M
COLOTTA, F
MOSCA, M
COLOMBO, N
BONAZZI, C
LANDONI, F
CORBETTA, G
MANTOVANI, A
ALLAVENA, P
[J]. INTERNATIONAL JOURNAL OF CANCER, 1995, 60 (03) : 300 - 307
[3] DIFFERENTIAL INDUCTION OF INTERCELLULAR-ADHESION MOLECULE-1 IN HUMAN SKIN BY RECOMBINANT CYTOKINES
BUCHSBAUM, ME
KUPPER, TS
MURPHY, GF
[J]. JOURNAL OF CUTANEOUS PATHOLOGY, 1993, 20 (01) : 21 - 27
[4] DINOTO R, 1996, LEUKEMIA, V8, P871
[5] DINOTO R, 1996, BRIT J HAEMATOL, V88, P247
[6] EXPRESSION OF ICAM-1, VCAM-1, L-SELECTIN, AND LEUKOSIALIN IN THE MOUSE CENTRAL-NERVOUS-SYSTEM DURING THE INDUCTION AND REMISSION STAGES OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
DOPP, JM
BRENEMAN, SM
OLSCHOWKA, JA
[J]. JOURNAL OF NEUROIMMUNOLOGY, 1994, 54 (1-2) : 129 - 144
[7] DUBOIS C, 1994, LEUKEMIA, V8, P1750
[8] Grimwade D, 1996, LEUKEMIA, V10, P61
[9] THE ROLE OF THE BLOOD-BRAIN-BARRIER IN HIV-INFECTION OF THE CENTRAL-NERVOUS-SYSTEM
HURWITZ, AA
BERMAN, JW
LYMAN, WD
[J]. ADVANCES IN NEUROIMMUNOLOGY, 1994, 4 (03): : 249 - 256
[10] All-trans-retinoic acid increases adhesion to endothelium of the human promyelocytic leukaemia cell line NB4
Marchetti, M
Falanga, A
Giovanelli, S
Oldani, E
Barbui, T
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1996, 93 (02) : 360 - 366

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