ABCG2: A potential marker of stem cells and novel target in stern cell and cancer therapy

被引：251

作者：

Ding, Xi-wei ^{[1
,2
]}

Wu, Jun-hua

Jiang, Chun-ping ^{[1
,2
]}

机构：

[1] Nanjing Univ, Dept Hepatobiliary Surg, Affiliated Drum Tower Hosp, Sch Med, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Univ, Inst Hepatobiliary Surg, Nanjing, Jiangsu, Peoples R China

来源：

LIFE SCIENCES | 2010年 / 86卷 / 17-18期

关键词：

ABCG2; Stem cells; Proliferation; Differentiation; Biomarkers; Cancer stem cells; SIDE POPULATION CELLS; RESISTANCE PROTEIN BCRP/ABCG2; BINDING CASSETTE TRANSPORTER; BREAST-CANCER; GENE-EXPRESSION; FUNCTIONAL EXPRESSION; UNTRANSLATED REGION; HEMATOPOIETIC-CELLS; DRUG-RESISTANCE; MESSENGER-RNA;

D O I：

10.1016/j.lfs.2010.02.012

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

ABCG2 is a member of the ATP binding cassette (ABC) transporters, which can pump a wide variety of endogenous and exogenous compounds out of cells. Widely expressed in stem cells, ABCG2 is also found to confer the side population phenotype and is recognized as a universal marker of stem cells. Although the precise physiological role of ABCG2 in stem cells is still unclear, existing data strongly suggest that ABCG2 plays an important role in promoting stem cell proliferation and the maintenance of the stem cell phenotype. In addition, ABCG2 is also found to be expressed in a number of cancer cells and appears to be a marker of cancer stem cells. Moreover, ABCG2 expression in tumors may contribute to their formation and progression. Thus. ABCG2 has potential applications in stem cell and tumor therapy. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：631 / 637

页数：7

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