Hepatoprotective diastereomeric lignans from Saururus chinensis herbs

被引：91

作者：

Sung, SH ^{[1
]}

Kim, YC ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 07期

关键词：

D O I：

10.1021/np990499e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new diastereomeric sauchinones (2, 3), along with the known sauchinone (1), a phenylpropanoid (sarisan), and two known lignans (galbacin and saucernetin), were isolated from the n-hexane fraction of Saururus chinensis using reversed-phase HPLC. The stereostructures of the lignans, sauchinone A (2) and 1'-epi-sauchinone (3), were established by analysis of spectroscopic data. Incubation of cultured rat hepatocytes intentionally injured by CCl4 with each of the compounds 1, 2, and 3 significantly reduced the levels of glutamic pyruvic transaminase released by the damaged hepatocytes.

引用

页码：1019 / 1021

页数：3

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