The effect of mechanical processing on surface stability of pharmaceutical powders: Visualization by atomic force microscopy

被引:42
作者
Begat, P [1 ]
Young, PM [1 ]
Edge, S [1 ]
Kaerger, JS [1 ]
Price, R [1 ]
机构
[1] Univ Bath, Dept Pharm & Pharmacol, Pharmaceut Technol Res Grp, Bath BA2 7AY, Avon, England
关键词
AFM; phase imaging; crystallization; salbutamol sulfate; amorphous; powders;
D O I
10.1002/jps.10320
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Atomic force microscopy was used to investigate the influence of mechanical processing (milling) on the surface stability of salbutamol sulfate. Phase imaging, a development of tapping mode(TM) atomic force microscopy, was used to elucidate variations in the physico-mechanical properties on the surface of salbutamol sulfate crystals by measuring the phase lag of an oscillating tip in contact with the surface. Simultaneous measurements of topographical and phase images indicated an increase in disorder on the surface as milling time was increased. Specific regions oil the milled samples, independent of topography, showed large variations in phase shift (>30degrees). These regions (not observed on the crystalline salbutamol sulfate) suggested large differences in the physical properties on the surface. It is therefore reasonable to conclude that these regions were likely attributed to mechanically induced amorphous domains. (C) 2003 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 92:611-620, 2003.
引用
收藏
页码:611 / 620
页数:10
相关论文
共 15 条
[1]   The use of isothermal microcalorimetry in the study of small degrees of amorphous content of a hydrophobic powder [J].
Ahmed, H ;
Buckton, G ;
Rawlins, DA .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 130 (02) :195-201
[2]   ATOMIC FORCE MICROSCOPE [J].
BINNIG, G ;
QUATE, CF ;
GERBER, C .
PHYSICAL REVIEW LETTERS, 1986, 56 (09) :930-933
[3]   SURFACE CHARACTERIZATION - UNDERSTANDING SOURCES OF VARIABILITY IN THE PRODUCTION AND USE OF PHARMACEUTICALS [J].
BUCKTON, G .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1995, 47 (04) :265-275
[4]   Water mobility in amorphous lactose below and close to the glass transition temperature [J].
Buckton, G ;
Darcy, P .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 136 (1-2) :141-146
[5]   A study of the crystallisation of amorphous salbutamol sulphate using water vapour sorption and near infrared spectroscopy [J].
Columbano, A ;
Buckton, G ;
Wikeley, P .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 237 (1-2) :171-178
[6]   Polymorphic discrimination using atomic force microscopy: Distinguishing between two polymorphs of the drug cimetidine [J].
Danesh, A ;
Chen, X ;
Davies, MC ;
Roberts, CJ ;
Sanders, GHW ;
Tendler, SJB ;
Williams, PM ;
Wilkins, MJ .
LANGMUIR, 2000, 16 (02) :866-870
[7]  
*DIG INSTR LTD, APPL NOT PHAS IMAG T
[8]   Determination of surface properties and how characteristics of salbutamol sulphate, before and after micronisation [J].
Feeley, JC ;
York, P ;
Sumby, BS ;
Dicks, H .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 172 (1-2) :89-96
[9]  
KRYCER I, 1981, INT J PHARM TECH PRO, V2, P55
[10]  
LEGER PJM, 1978, ACTA CRYSTALLOGR B, V34, P1203