学术探索
学术期刊
新闻热点
数据分析
智能评审

Basic mechanisms of humoral rejection

被引：13
作者：
Cascalho, M
Platt, JL
机构：
[1] Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Dept Surg, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Dept Pediat, Rochester, MN 55905 USA
来源：
PEDIATRIC TRANSPLANTATION | 2005年 / 9卷 / 01期
关键词：
antibodies; allograft; ABO blood groups; HLA; graft rejection; B cells;
D O I：
10.1111/j.1399-3046.2004.00231.x
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Humoral rejection is among the most vexing problems afflicting organ transplants. Triggered by antibodies predominantly against donor human leukocyte (HLA), humoral rejection can now be understood through consideration of basic mechanisms of immunity to foreign antigens and impact of humoral immunity on blood vessels. Basic considerations may also shed light on mechanisms by which various treatments have recently brought about vastly improved outcomes.
引用
收藏
页码：9 / 16
页数：8
相关论文
共 53 条
[1]  
ALEXANDRE GPJ, 1985, TRANSPLANT P, V17, P138
[2]  
ALEXANDRE GPJ, 1987, TRANSPLANT P, V19, P4538
[3]   Anti-CD20 monoclonal antibody (rituximab) therapy for acute cardiac humoral rejection: A case report [J].
Aranda, JM ;
Scornik, JC ;
Normann, SJ ;
Lottenberg, R ;
Schofield, RS ;
Pauly, DF ;
Miles, M ;
Hill, JA ;
Sleasman, JW ;
Skoda-Smith, S .
TRANSPLANTATION, 2002, 73 (06) :907-910
[4]   Accommodation of vascularized xenografts: Expression of ''protective genes'' by donor endothelial cells in a host Th2 cytokine environment [J].
Bach, FH ;
Ferran, C ;
Hechenleitner, P ;
Mark, W ;
Koyamada, N ;
Miyatake, T ;
Winkler, H ;
Badrichani, A ;
Candinas, D ;
Hancock, WW .
NATURE MEDICINE, 1997, 3 (02) :196-204
[5]  
BANNETT AD, 1989, TRANSPLANT P, V21, P783
[6]  
BANNETT AD, 1987, TRANSPLANT P, V19, P4543
[7]   PLASMAPHERESIS - ADJUNCTIVE TREATMENT FOR STEROID-RESISTANT REJECTION IN RENAL-TRANSPLANTATION [J].
BANOWSKY, LHW ;
CORTESE, J ;
LUTTON, JJ ;
SAUNDERS, PH .
JOURNAL OF UROLOGY, 1984, 131 (01) :14-16
[8]   Platelet-mediated activation of endothelial cells: Implications for the pathogenesis of transplant rejection [J].
Bustos, M ;
Saadi, S ;
Platt, JL .
TRANSPLANTATION, 2001, 72 (03) :509-515
[9]   B cells and professional APCs recruit regulatory T cells via CCL4 [J].
Bystry, RS ;
Aluvihare, V ;
Welch, KA ;
Kallikourdis, M ;
Betz, AG .
NATURE IMMUNOLOGY, 2001, 2 (12) :1126-1132
[10]  
CHOPEK MW, 1987, TRANSPLANT P, V19, P4553
123456