Simultaneous determination of neutral and acidic pharmaceuticals in wastewater by high-performance liquid chromatography-post-column photochemically induced fluorimetry

被引：47

作者：

González-Barreiro, C ^{[1
]}

Lores, M ^{[1
]}

Casais, MC ^{[1
]}

Cela, R ^{[1
]}

机构：

[1] Univ Santiago Compostela, Fac Quim, Dept Quim Anal Nutr & Bromatol, E-15706 Santiago, Spain

来源：

JOURNAL OF CHROMATOGRAPHY A | 2003年 / 993卷 / 1-2期

关键词：

water analysis; photochemically induced fluorimetric detection; detection; LC; derivatization; LQ; optimization; drugs; carbamazepine; diazepam; diclofenac; ketoprofen; profens; naproxen;

D O I：

10.1016/S0021-9673(03)00392-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An analytical method for the simultaneous determination of acidic and neutral pharmaceutical active compound (PhACs) residues in wastewater has been developed based on the combination of high-performance liquid chromatography (HPLC) and photochemically induced fluorimetry. The photoderivatization conditions for each particular PhAC have been assessed. Off-line optimization of the HPLC separation for both neutral and acidic compounds has been utilised and evaluated. Detection limits in the low ng/ml range have been achieved without sample pretreatment. By applying the developed analytical method combined with solid-phase extraction to real wastewater samples an enrichment factor of approximately two orders of magnitude can be obtained. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：29 / 37

页数：9

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