Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke

被引：285

作者：

Erdö, F

Bührle, C

Blunk, J

Hoehn, M

Xia, T

Fleischmann, B

Föcking, M

Küstermann, E

Kolossov, E

Hescheler, T

Hossmann, KA

Trapp, T

机构：

[1] Max Planck Inst Neurol Res, Dept Expt Neurol, D-50931 Cologne, Germany

[2] Univ Cologne, Inst Neurophysiol, Cologne, Germany

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2003年 / 23卷 / 07期

关键词：

embryonic stems cells; brain infarction; cell replacement therapy; tumorigenesis; xenotransplantation; IN-VITRO; HUMAN BLASTOCYSTS; DOPAMINE NEURONS; PRECURSOR CELLS; RAT MODEL; DIFFERENTIATION; REPLACEMENT; DISEASE; LINES;

D O I：

10.1097/01.WCB.0000071886.63724.FB

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The therapeutical potential of transplantation of undifferentiated and predifferentiated murine embryonic stem cells for the regeneration of the injured brain was investigated in two rodent stroke models. Undifferentiated embryonic stem cells xenotransplanted into the rat brain at the hemisphere opposite to the ischemic injury migrated along the corpus callosum towards the damaged tissue and differentiated into neurons in the border zone of the lesion. In the homologous mouse brain, the same murine embryonic stem cells did not migrate, but produced highly malignant teratocarcinomas at the site of implantation, independent of whether they were predifferentiated in vitro to neural progenitor cells. The authors demonstrated a hitherto unrecognized inverse outcome after xenotransplantation and homologous transplantation of embryonic stem cells, which raises concerns about safety provisions when the therapeutical potential of human embryonic stem cells is tested in preclinical animal models.

引用

页码：780 / 785

页数：6

共 22 条

[1] Differentiation of green fluorescent protein-labeled embryonic stem cell-derived neural precursor cells into Thy-1-positive neurons and glia after transplantation into adult rat striatum [J].