High-throughput screening: new technology for the 21st century

被引：397

作者：

Hertzberg, RP

Pope, AJ

机构：

[1] SmithKline Beecham Pharmaceut, Mol Screening Technol, King Of Prussia, PA 19406 USA

[2] SmithKline Beecham Pharmaceut, Mol Interact & New Assay Technol, Harlow CM19 5AW, Essex, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(00)00110-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New technologies in high-throughput screening have significantly increased throughput and reduced assay volumes. Key advances over the past few years include new fluorescence methods, detection platforms and liquid-handling technologies. Screening 100,000 samples per day in miniaturized assay volumes will soon become routine. Furthermore, new technologies are now being applied to information-rich cell-based assays, and this is beginning to remove one of the key bottlenecks downstream from primary screening.

引用

收藏

页码：445 / 451

页数：7

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