Efficient synthesis of unsymmetrical 1,4-disubstituted-2,3-diketopiperazines via tandem reductive amination-cyclization

被引：11

作者：

Beshore, DC ^{[1
]}

Dinsmore, CJ ^{[1
]}

机构：

[1] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(00)01565-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we report the efficient syntheses of 1,4-disubstituted-2,3-diketopiperazines and 1,4,5-trisubstituted-2,3-diketopiperazines, which feature a tandem reductive amination and acylation. Aliphatic and aromatic primary amines serve as viable nucleophiles under the mild reaction conditions. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：8735 / 8739

页数：5

共 17 条

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