The mechanism of phospholipase C-γ1 regulation

被引：64

作者：

Kim, MJ ^{[1
]}

Kim, E ^{[1
]}

Ryu, SH ^{[1
]}

Suh, PG ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Life Sci, Div Mol & Life Sci, Kyungbuk 790784, South Korea

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2000年 / 32卷 / 03期

关键词：

phospholipase C; protein kinase C;

D O I：

10.1038/emm.2000.18

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phospholipase C (PLC)(1) hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-gamma 1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-gamma 1.

引用

页码：101 / 109

页数：9

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