Evaluation of risperidone in the neonatal 6-hydroxydopamine model of Lesch-Nyhan syndrome

被引：12

作者：

Allen, SM ^{[1
]}

Freeman, JN

Davis, WM

机构：

[1] Univ Mississippi, Dept Pharmacol, University, MS 38677 USA

[2] Univ Mississippi, Res Inst Pharmacol Sci, University, MS 38677 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1998年 / 59卷 / 02期

关键词：

risperidone; 6-hydroxydopamine; SCH-23390; serotonin; dopamine; self-mutilation;

D O I：

10.1016/S0091-3057(97)00411-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Rats were treated as neonates with 6-hydroxydopamine (6-OHDA) 100 mg free base in 10 mu l intracisternally. Upon maturation, animals were injected with L-dopa and placed in photocell cages for monitoring of locomotion, stereotypies, and self-mutilation. Pretreatment with either risperidone or SCH-23390 significantly reduced locomotion and stereotypies. SCH-23390 eliminated L-dopa induced self-mutilation in all subjects, while risperidone eliminated self-mutilation in all but one subject. (C) 1998 Elsevier Science Inc.

引用

页码：327 / 330

页数：4

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