Intercalation of mefenamic and meclofenamic acid anions in hydrotalcite-like matrixes

被引：43

作者：

del Arco, M. ^{[1
]}

Fernandez, A. ^{[1
]}

Martin, C. ^{[1
]}

Rives, V. ^{[1
]}

机构：

[1] Univ Salamanca, Dept Quim Inorgan, E-37008 Salamanca, Spain

来源：

APPLIED CLAY SCIENCE | 2007年 / 36卷 / 1-3期

关键词：

hydrotalcite drug intercalation; mefenamic acid; layered double hydroxides; meclofenamic acid; LAYERED DOUBLE HYDROXIDES; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SOLUBILITY; EXCHANGE; CLAYS;

D O I：

10.1016/j.clay.2006.04.011

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Layered double hydroxides with Mg and Al cations in the layers (Mg/Al molar ratio 2) and with intercalated mefenamic and meclofenamic acid anions have been prepared by coprecipitation, ion exchange and reconstruction. The solids have been characterized by X-ray diffraction, FTIR spectroscopy and assessment of specific surface area; their thermal stability has been studied by differential thermal and thermogravimetric analyses. Intercalation has been achieved by all three methods used, the gallery height ranging between 16.5 and 17.5 angstrom, depending on the particular drying conditions, these values suggesting the organic molecules form bilayers in the interlayer space. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：133 / 140

页数：8

共 30 条

[1]

Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs [J].