Neurons and glia: team players in axon guidance

被引:77
作者
Chotard, C [1 ]
Salecker, I [1 ]
机构
[1] Natl Inst Med Res, Div Mol Neurobiol, London NW7 1AA, England
基金
英国医学研究理事会;
关键词
D O I
10.1016/j.tins.2004.09.001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the developing nervous system, growth cones follow specific trajectories to reach their target area and ultimately connect with their correct postsynaptic partners. This review focuses on studies in both Drosophila and vertebrates to highlight that mutual interactions between neurons and glia are essential in forming specific neuronal connections. Glia signal to neurons to direct pathfinding and targeting of axons, as well as to stabilize and refine axonal branches within the target area. Equally, neurons provide crucial information to glia, supporting their migration and correct positioning.
引用
收藏
页码:655 / 661
页数:7
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