Elastin polymorphism haplotype and intracranial aneurysms are not associated in Central Europe

被引：45

作者：

Hofer, A

Hermans, M

Kubassek, N

Sitzer, M

Funke, H

Stögbauer, F

Ivaskevicius, V

Oldenburg, J

Burtscher, J

Knopp, U

Schoch, B

Wanke, I

Hübner, F

Deinsberger, W

Meyer, B

Boecher-Schwarz, H

Poewe, W

Raabe, A

Steinmetz, H

Auburger, G

机构：

[1] Univ Frankfurt, Dept Neurol, D-60590 Frankfurt, Germany

[2] Univ Frankfurt, Dept Neurosurg, D-6000 Frankfurt, Germany

[3] Univ Frankfurt, Inst Transfus Med & Immunohaematol, D-6000 Frankfurt, Germany

[4] Univ Munster, Dept Clin Chem & Lab Med, D-4400 Munster, Germany

[5] Univ Munster, Dept Neurol, D-4400 Munster, Germany

[6] Leopold Franzens Univ Innsbruck, Dept Neurosurg, Innsbruck, Austria

[7] Leopold Franzens Univ Innsbruck, Dept Neurol, Innsbruck, Austria

[8] Univ Lubeck, Dept Neurosurg, Lubeck, Germany

[9] Univ Essen Gesamthsch, Dept Neurosurg, Essen, Germany

[10] Univ Essen Gesamthsch, Dept Neuroradiol, Essen, Germany

[11] Univ Ulm, Dept Neurosurg, D-89069 Ulm, Germany

[12] Univ Giessen, Dept Neurosurg, D-35390 Giessen, Germany

[13] Univ Bonn, Dept Neurosurg, D-5300 Bonn, Germany

[14] Univ Mainz, Dept Neurosurg, D-6500 Mainz, Germany

来源：

STROKE | 2003年 / 34卷 / 05期

关键词：

elastin; genetics; intracranial aneurysm; polymorphism; single nucleotide; subarachnoid hemorrhage;

D O I：

10.1161/01.STR.0000069013.83336.1C

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose - The occurrence of intracranial aneurysms and of aneurysmal subarachnoid hemorrhage are influenced by genetic factors. Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients. Methods - We have genotyped 2 single nucleotide polymorphisms in the elastin gene and evaluated their allelic association with intracranial aneurysm in a Central European sample of 30 familial and 175 sporadic patients and 235 population controls. Results - We found no allelic association between this elastin polymorphism haplotype and intracranial aneurysm. Conclusion - Our data probably reflect increased genetic heterogeneity of intracranial aneurysm in Europe compared with Japan.

引用

页码：1207 / 1211

页数：5

共 31 条

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