Still stratus not altocumulus: Further evidence against the date/party hub distinction

被引：84

作者：

Batada, Nizar N. ^{[1
]}

Reguly, Teresa

Breitkreutz, Ashton

Boucher, Lorrie

Breitkreutz, Bobby-Joe

Hurst, Laurence D.

Tyers, Mike

机构：

[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

[2] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[3] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON, Canada

来源：

PLOS BIOLOGY | 2007年 / 5卷 / 06期

关键词：

EVOLUTIONARY; ARCHITECTURE; MODULARITY;

D O I：

10.1371/journal.pbio.0050154

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the new filtered-HC dataset, as in others, the two definitional criteria of date/party hubs find no support. Four corollary points of evidence - rate of evolution, effect of deletion on network topology, genetic connectivity, and hub status quo - also find no support. That across multiple datasets, and under multiple different tests, we repeatedly find no evidence for the date/party hypothesis suggests that network hubs do not fall into discrete classes. © 2007 Batada et al.

引用

页码：1202 / 1206

页数：5

共 15 条

[1] Evolutionary and physiological importance of hub proteins
Batada, Nizar N.
Hurst, Laurence D.
Tyers, Mike
[J]. PLOS COMPUTATIONAL BIOLOGY, 2006, 2 (07) : 748 - 756
[2] Stratus not altocumulus: A new view of the yeast protein interaction network
Batada, Nizar N.
Reguly, Teresa
Breitkreutz, Ashton
Boucher, Lorrie
Breitkreutz, Bobby-Joe
Hurst, Laurence D.
Tyers, Mike
[J]. PLOS BIOLOGY, 2006, 4 (10) : 1720 - 1731
[3] Why highly expressed proteins evolve slowly
Drummond, DA
Bloom, JD
Adami, C
Wilke, CO
Arnold, FH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (40) : 14338 - 14343
[4] Modularity and evolutionary constraint on proteins
Fraser H.B.
[J]. Nature Genetics, 2005, 37 (4) : 351 - 352
[5] Proteome survey reveals modularity of the yeast cell machinery
Gavin, AC
Aloy, P
Grandi, P
Krause, R
Boesche, M
Marzioch, M
Rau, C
Jensen, LJ
Bastuck, S
Dümpelfeld, B
Edelmann, A
Heurtier, MA
Hoffman, V
Hoefert, C
Klein, K
Hudak, M
Michon, AM
Schelder, M
Schirle, M
Remor, M
Rudi, T
Hooper, S
Bauer, A
Bouwmeester, T
Casari, G
Drewes, G
Neubauer, G
Rick, JM
Kuster, B
Bork, P
Russell, RB
Superti-Furga, G
[J]. NATURE, 2006, 440 (7084) : 631 - 636
[6] Functional organization of the yeast proteome by systematic analysis of protein complexes
Gavin, AC
Bösche, M
Krause, R
Grandi, P
Marzioch, M
Bauer, A
Schultz, J
Rick, JM
Michon, AM
Cruciat, CM
Remor, M
Höfert, C
Schelder, M
Brajenovic, M
Ruffner, H
Merino, A
Klein, K
Hudak, M
Dickson, D
Rudi, T
Gnau, V
Bauch, A
Bastuck, S
Huhse, B
Leutwein, C
Heurtier, MA
Copley, RR
Edelmann, A
Querfurth, E
Rybin, V
Drewes, G
Raida, M
Bouwmeester, T
Bork, P
Seraphin, B
Kuster, B
Neubauer, G
Superti-Furga, G
[J]. NATURE, 2002, 415 (6868) : 141 - 147
[7] Evidence for dynamically organized modularity in the yeast protein-protein interaction network
Han, JDJ
Bertin, N
Hao, T
Goldberg, DS
Berriz, GF
Zhang, LV
Dupuy, D
Walhout, AJM
Cusick, ME
Roth, FP
Vidal, M
[J]. NATURE, 2004, 430 (6995) : 88 - 93
[8] THE DIP TEST OF UNIMODALITY
HARTIGAN, JA
HARTIGAN, PM
[J]. ANNALS OF STATISTICS, 1985, 13 (01) : 70 - 84
[9] HARTIGAN PM, 1985, J R STAT SOC C-APPL, V34, P320
[10] Adjusting for selection on synonymous sites in estimates of evolutionary distance
Hirsh, AE
Fraser, HB
Wall, DP
[J]. MOLECULAR BIOLOGY AND EVOLUTION, 2005, 22 (01) : 174 - 177

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