CD44 and its partners in metastasis

被引：150

作者：

Jothy, S

机构：

[1] St Michaels Hosp, Dept Lab Med & Pathobiol, Toronto, ON M5B 1W8, Canada

[2] Univ Toronto, Toronto, ON, Canada

来源：

CLINICAL & EXPERIMENTAL METASTASIS | 2003年 / 20卷 / 03期

基金：

加拿大健康研究院;

关键词：

CD44; cell adhesion; metastasis;

D O I：

10.1023/A:1022931016285

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The establishment of metastasis requires that tumor cells acquire new adhesion and migration properties to emigrate from primary sites and colonize distant organs. CD44 is a cell membrane protein often overexpressed on tumor cells and, being both a cell-cell and cell-extracellular matrix adhesion protein, is well positioned to contribute to this process. Furthermore the interaction of CD44 with other cellular proteins involved in motogenesis and proteolysis is a determinant factor in cell migration and invasion. This review summarizes current knowledge on the role of CD44 in metastasis, as well as the challenges on understanding how this process operates.

引用

页码：195 / 201

页数：7

共 57 条

[1] Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid [J].