Synthesis of coumarins via palladium-catalyzed carbonylative annulation of internal alkynes by o-iodophenols

被引：133

作者：

Kadnikov, DV ^{[1
]}

Larock, RC ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 23期

关键词：

D O I：

10.1021/ol0065569

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A variety of substituted coumarins have been prepared in good yields by the palladium-catalyzed coupling of o-iodophenols with internal alkynes and 1 atm of carbon monoxide, Unlike most of the previous work on the palladium catalyzed carbonylation of alkynes, the insertion of the internal alkyne occurs in preference to the insertion of CO.

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页码：3643 / 3646

页数：4

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