Rapid, efficient and selective reduction of aromatic nitro compounds with sodium borohydride and Raney nickel

被引:118
作者
Pogorelic, Ivan [1 ]
Filipan-Litvic, Mirela [1 ]
Merkas, Sonja [1 ]
Ljubic, Goranka [1 ]
Cepanec, Ivica [1 ]
Litvic, Mladen [1 ]
机构
[1] BELUPO Pharmaceut Inc, R&D, CRO-10000 Zagreb, Croatia
关键词
reduction; nitro group; aromatic amines; Raney nickel; sodium borohydride;
D O I
10.1016/j.molcata.2007.05.020
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A new efficient, mild and practical method for reduction of aromatic nitro compounds employing NaBH4/Raney nickel system is reported. The method is simple, inexpensive, easily scaled-up and applicable for large scale preparation of different substituted anilines as well as other heterocyclic aryl amines. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:202 / 207
页数:6
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