Receptor-like Cytoplasmic Kinases Integrate Signaling from Multiple Plant Immune Receptors and Are Targeted by a Pseudomonas syringae Effector

被引：674

作者：

Zhang, Jie ^{[1
]}

Li, Wei ^{[1
]}

Xiang, Tingting ^{[1
,2
]}

Liu, Zixu ^{[1
]}

Laluk, Kristin ^{[3
]}

Ding, Xiaojun ^{[1
]}

Zou, Yan ^{[1
]}

Gao, Minghui ^{[1
]}

Zhang, Xiaojuan ^{[1
]}

Chen, She ^{[1
]}

Mengiste, Tesfaye ^{[3
]}

Zhang, Yuelin ^{[1
]}

Zhou, Jian-Min ^{[1
]}

机构：

[1] Natl Inst Biol Sci, Beijing 102209, Peoples R China

[2] China Agr Univ, Coll Biol Sci, State Key Lab Plant Physiol & Biochem, Beijing 100094, Peoples R China

[3] Purdue Univ, Dept Bot & Plant Pathol, W Lafayette, IN 47907 USA

来源：

CELL HOST & MICROBE | 2010年 / 7卷 / 04期

关键词：

E3 UBIQUITIN LIGASE; INNATE IMMUNITY; III EFFECTOR; CELL-DEATH; DISEASE RESISTANCE; FLAGELLIN PERCEPTION; BACTERIAL FLAGELLIN; ARABIDOPSIS PLANTS; DEFENSE RESPONSES; MPK4; ACTIVATION;

D O I：

10.1016/j.chom.2010.03.007

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cell-surface-localized plant immune receptors, such as FLS2, detect pathogen-associated molecular patterns (PAMPs) and initiate PAMP-triggered immunity (PTI) through poorly understood signal-transduction pathways. The pathogenic Pseudomonas syringae effector AvrPphB, a cysteine protease, cleaves the Arabidopsis receptor-like cytoplasmic kinase PBS1 to trigger cytoplasmic immune receptor RPS5-specified effector-triggered immunity (ETI). Analyzing the function of AvrPphB in plants lacking RPS5, we find that AvrPphB can inhibit PTI by cleaving additional PBS1-like (PBL) kinases, including BIK1, PBL1, and PBL2. In unstimulated plants, BIK1 and PBL1 interact with FLS2 and are rapidly phosphorylated upon FLS2 activation by its ligand flg22. Genetic and molecular analyses indicate that BIK1, and possibly PBL1, PBL2, and PBS1, integrate immune signaling from multiple immune receptors. Whereas AvrPphB-mediated degradation of one of these kinases, PBS1, is monitored by RPS5 to initiate ETI, this pathogenic effector targets other PBL kinases for PTI inhibition.

引用

页码：290 / 301

页数：12

共 52 条

[1] Type III effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity [J].