Effect of vigabatrin on glutainate dehydrogenase in the hippocampus of seizure prone gerbils

被引：9

作者：

Kang, TC ^{[1
]}

An, SJ

Park, SK

Hwang, IK

Choi, SY

Kwon, OS

Won, MH

机构：

[1] Hallym Univ, Coll Med, Dept Anat, Chunchon 200702, South Korea

[2] Hallym Univ, Coll Life Sci, Dept Genet Engn, Chunchon 200702, South Korea

[3] Kyungpook Natl Univ, Coll Nat Sci, Dept Biochem, Taegu 702701, South Korea

来源：

NEUROSCIENCE LETTERS | 2003年 / 340卷 / 02期

关键词：

glutamate dehydrogenase; vigabatrin; seizure; gerbil; epilepsy; hippocampus;

D O I：

10.1016/S0304-3940(03)00072-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Vigabatrin (VGB, gamma-vinyl-gamma-aminobutyric acid (GABA)), an irreversible inhibitor of GABA transaminase, increases regional inhibitory effects by elevating GABA concentration and reducing glutamate synthesis. In the present study, changes in glutamate dehydrogenase (GDH) activity and its immunoreactivity in the seizure prone gerbil hippocampus after treating VGB were investigated to identify the effect of VGB on energy and/or glutamate metabolism via GDH. In the VGB treated group, GDH immunoreactivity and its activity in the hippocampus were significantly decreased, as compared with those of controls. These findings suggest that VGB administration may suppress the development and spread of seizures not only by elevating the level of GABA, but also by affecting the glutamate signaling and energy metabolism in neurons. (C) 2003 Elsevier Science Ireland Ltd. All fights reserved.

引用

页码：115 / 118

页数：4

共 20 条

[1] COADMINISTRATION OF VIGABATRIN AND VALPROATE IN CHILDREN WITH REFRACTORY EPILEPSY [J].

ARMIJO, JA ;

ARTEAGA, R ;

VALDIZAN, EM ;

HERRANZ, JL .

CLINICAL NEUROPHARMACOLOGY, 1992, 15 (06) :459-469

[2] Glutamate, GABA and epilepsy [J].

Bradford, HF .

PROGRESS IN NEUROBIOLOGY, 1995, 47 (06) :477-511

[3] 2 SOLUBLE FORMS OF GLUTAMATE-DEHYDROGENASE ISOPROTEINS FROM BOVINE BRAIN [J].

CHO, SW ;

LEE, JW ;

CHOI, SY .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 233 (01) :340-346

[4]

FISHER HF, 1985, METHOD ENZYMOL, V113, P16

[5] EFFECTS OF VIGABATRIN (GAMMA-VINYL GABA) ON NEUROTRANSMISSION-RELATED AMINO-ACIDS AND ON GABA AND BENZODIAZEPINE RECEPTOR-BINDING IN RATS [J].

HALONEN, T ;

PITKANEN, A ;

SAANO, V ;

RIEKKINEN, PJ .

EPILEPSIA, 1991, 32 (02) :242-249

[6]

HASSEL B, 1995, J NEUROCHEM, V64, P2773

[7]

Hassel B, 1998, J NEUROCHEM, V71, P1511

[8]

Ketter TA, 1999, NEUROLOGY, V53, pS53

[9] INCREASED ENKEPHALIN AND DYNORPHIN IMMUNOREACTIVITY IN THE HIPPOCAMPUS OF SEIZURE SENSITIVE MONGOLIAN GERBILS [J].

LEE, RJ ;

HONG, JS ;

MCGINTY, JF ;

LOMAX, P .

BRAIN RESEARCH, 1987, 401 (02) :353-358

[10]

LOSCHER W, 1994, BRIT J PHARMACOL, V112, P97

← 1 2 →