Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin, and Melanocortins

被引:407
作者
Hall, John E. [1 ]
da Silva, Alexandre A. [1 ]
do Carmo, Jussara M. [1 ]
Dubinion, John [1 ]
Hamza, Shereen [1 ]
Munusamy, Shankar [1 ]
Smith, Grant [1 ]
Stec, David E. [1 ]
机构
[1] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA
基金
美国国家卫生研究院;
关键词
BLOOD-PRESSURE; ARTERIAL-PRESSURE; MICE; ACTIVATION; EPIDEMICS; WEIGHT; KIDNEY;
D O I
10.1074/jbc.R110.113175
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Excess weight gain contributes to increased blood pressure in most patients with essential hypertension. Although the mechanisms of obesity hypertension are not fully understood, increased renal sodium reabsorption and impaired pressure natriuresis play key roles. Several mechanisms contribute to altered kidney function and hypertension in obesity, including activation of the sympathetic nervous system, which appears to be mediated in part by increased levels of the adipocyte-derived hormone leptin, stimulation of pro-opiomelanocortin neurons, and subsequent activation of central nervous system melanocortin 4 receptors.
引用
收藏
页码:17271 / 17276
页数:6
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