TNFB gene polymorphism in insulin-dependent diabetes mellitus: association with HLA-DR alleles

被引：6

作者：

Newton, DJ

Bowen-Jones, D

Crosby, I

Barnes, RMR

Flanagan, BF

机构：

[1] Univ Liverpool, Dept Immunol, Liverpool L69 3GA, Merseyside, England

[2] Arrowe Pk Hosp, Wirral, Merseyside, England

[3] RLUH, Dept Immunol, Liverpool, Merseyside, England

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 1998年 / 25卷 / 01期

关键词：

D O I：

10.1046/j.1365-2370.1998.00088.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A polymorphism of the TNF-beta gene can be detected by restriction digestion of a PCR product with NcoI. In this study we look at the risk associated with this polymorphism in a study of 69 insulin-dependent diabetes patients and 119 healthy controls. The risk was further characterized by comparison to the HLA type of the individual, since the TNF polymorphism is in linkage disequilibrium with HLA genes.

引用

页码：39 / 41

页数：3

共 18 条

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