Cytochrome p450 enzymes and cardiovascular disease

被引：21

作者：

Hunter, AL ^{[1
]}

Cruz, RP ^{[1
]}

Cheyne, BM ^{[1
]}

McManus, BM ^{[1
]}

Granville, DJ ^{[1
]}

机构：

[1] Univ British Columbia, James Hogg iCAPTURE Ctr Cardiovasc & Pulm Res, St Pauls Hosp, Vancouver, BC V6Z 1Y6, Canada

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2004年 / 82卷 / 12期

关键词：

cytochrome p450; heart; endothelial cell; ischemia; atherosclerosis; reactive oxygen species;

D O I：

10.1139/Y04-118

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cytochrome p450 (CYP) superfamily is responsible for the oxidation, peroxidation, and (or) reduction of vitamins, steroids, xenobiotics, and the majority of cardiovascular drugs in an oxygen- and NADPH-dependent manner. Although hepatic CYP have been studied extensively, the role of CYP in cardiovascular physiology and disease is poorly understood. Increasing evidence suggests that these enzymes play an important role in the pathogenesis of a number of cardiovascular diseases. The current review summarizes the understanding as to the role that dysregulated CYP expression and (or) activity may play in the onset and progression of cardiovascular disease.

引用

页码：1053 / 1060

页数：8

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