Bradykinin antagonists: new opportunities

被引：50

作者：

Bock, MG ^{[1
]}

Longmore, J

机构：

[1] Merck Res Labs, W Point, PA 19486 USA

[2] Merck Sharp & Dohme Ltd, Res Labs, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(00)00107-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pro-inflammatory, pain producing, and cardiovascular effects of bradykinin B-2 receptor activation are well characterized. Bradykinin B-1 receptors also produce inflammation and pain. Therefore, antagonists are expected to be anti-inflammatory/analgesic drugs. Other exploitable clinical opportunities may exist. The newly discovered non-peptide B-2 receptor antagonists and the equivalent B-1 receptor pharmacological agents, which are in the pipeline, are suitable preclinical tools to properly evaluate potential utilities.

引用

页码：401 / 406

页数：6

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