Modulation of iTBS after-effects via concurrent directional TDCS: A proof of principle study

被引:19
作者
Tremblay, Sara [1 ]
Hannah, Ricci [1 ]
Rawji, Vishal [1 ]
Rothwell, John C. [1 ]
机构
[1] UCL Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London, England
基金
英国医学研究理事会;
关键词
Transcranial magnetic stimulation; Intermittent theta burst stimulation; Transcranial direct current stimulation; Primary motor cortex; TRANSCRANIAL MAGNETIC STIMULATION; HUMAN MOTOR CORTEX; THETA-BURST STIMULATION; EXCITABILITY; PLASTICITY; DURATION;
D O I
10.1016/j.brs.2017.03.009
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Background: Polarising currents can modulate membrane potentials in animals, affecting the after-effect of theta burst stimulation (TBS) on synaptic strength. Objective: We examined whether a similar phenomenon could also be observed in human motor cortex (M1) using transcranial direct current stimulation (TDCS) during monophasic intermittent TBS (iTBS). Methods: TDCS was applied during posterior-anterior iTBS using three different conditions: posterior anterior TDCS (anode 3.5 cm posterior to Ml, cathode 3.5 cm anterior to M1), anterior-posterior TDCS (cathode 3.5 cm posterior to Ml, anode 3.5 cm anterior to M1), and sham TDCS. Results: When the direction of TDCS (posterior-anterior) matched the direction of the electrical field induced by iTBS, we found a 19% non-significant increase in excitability changes in comparison with iTBS combined with sham TDCS. When the TDCS was reversed (anterior-posterior), the excitatory effect of iTBS was abolished. Conclusion: Our findings suggest that excitatory aftereffects of iTBS can be modulated by directionally specific TDCS. (C) 2017 The Authors. Published by Elsevier Inc.
引用
收藏
页码:744 / 747
页数:4
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