Phosphoinositide 3-kinases: A conserved family of signal transducers

被引：822

作者：

Vanhaesebroeck, B ^{[1
]}

Leevers, SJ ^{[1
]}

Panayotou, G ^{[1
]}

Waterfield, MD ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,DEPT BIOCHEM & MOL BIOL,LONDON WC1E 6BT,ENGLAND

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(97)01061-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane traffic. Several distinct classes of PI3Ks have now been identified that have been conserved throughout eukaryotic evolution. Potential signalling pathways downstream of PI3Ks have been elucidated and PI3K function is now being characterised in several model organisms.

引用

页码：267 / 272

页数：6

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