Coadministration of DNA encoding interleukin-6 and hemagglutinin confers protection from influenza virus challenge in mice

被引：57

作者：

Larsen, DL

Dybdahl-Sissoko, N

McGregor, MW

Drape, R

Neumann, V

Swain, WF

Lunn, DP

Olsen, CW

机构：

[1] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA

[2] Univ Wisconsin, Sch Vet Med, Dept Med Sci, Madison, WI 53706 USA

[3] PowderJect Vaccines Inc, Madison, WI 53711 USA

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 02期

关键词：

D O I：

10.1128/JVI.72.2.1704-1708.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study was conducted to investigate whether Accell gene gun coadministration of DNA encoding human interleukin-6 (IL-6) would enhance protective immune responses in mice to an equine influenza A virus hemagglutinin (HA) DNA vaccine. Mice that received HA DNA alone exhibited accelerated clearance of homologous challenge virus but were not protected from infection, In contrast, mice that received both HA and IL-6 DNA had no detectable virus in their lungs after challenge, These results strongly support the use of IL-6 as a cytokine adjuvant in DNA vaccination.

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页码：1704 / 1708

页数：5

相关论文

共 47 条

[1] PRODUCTION OF HYBRIDOMA GROWTH-FACTOR BY HUMAN-MONOCYTES [J].

AARDEN, LA ;

DEGROOT, ER ;

SCHAAP, OL ;

LANSDORP, PM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (10) :1411-1416

[2]

[Anonymous], 1996, MMWR Recomm Rep, V45, P1

[3] Oral immunization with a replication-deficient recombinant vaccinia virus protects mice against influenza [J].

Bender, BS ;

Rowe, CA ;

Taylor, SF ;

Wyatt, LS ;

Moss, B ;

Small, PA .

JOURNAL OF VIROLOGY, 1996, 70 (09) :6418-6424

[4] Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2 [J].

Chow, YH ;

Huang, WL ;

Chi, WK ;

Chu, YD ;

Tao, MH .

JOURNAL OF VIROLOGY, 1997, 71 (01) :169-178

[5] DOSE-RESPONSE OF A/ALASKA/6/77 (H3N2) COLD-ADAPTED REASSORTANT VACCINE VIRUS IN ADULT VOLUNTEERS - ROLE OF LOCAL ANTIBODY IN RESISTANCE TO INFECTION WITH VACCINE VIRUS [J].

CLEMENTS, ML ;

ODONNELL, S ;

LEVINE, MM ;

CHANOCK, RM ;

MURPHY, BR .

INFECTION AND IMMUNITY, 1983, 40 (03) :1044-1051

[6] Characterization of humoral immune responses induced by an influenza hemagglutinin DNA vaccine [J].

Deck, RR ;

DeWitt, CM ;

Donnelly, JJ ;

Liu, MA ;

Ulmer, JB .

VACCINE, 1997, 15 (01) :71-78

[7] IMMUNIZATION WITH DNA [J].

DONNELLY, JJ ;

ULMER, JB ;

LIU, MA .

JOURNAL OF IMMUNOLOGICAL METHODS, 1994, 176 (02) :145-152

[8] DNA VACCINES - A NOVEL-APPROACH TO IMMUNIZATION [J].

FYNAN, EF ;

WEBSTER, RG ;

FULLER, DH ;

HAYNES, JR ;

SANTORO, JC ;

ROBINSON, HL .

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1995, 17 (02) :79-83

[9] DNA VACCINES - PROTECTIVE IMMUNIZATIONS BY PARENTERAL, MUCOSAL, AND GENE-GUN INOCULATIONS [J].

FYNAN, EF ;

WEBSTER, RG ;

FULLER, DH ;

HAYNES, JR ;

SANTORO, JC ;

ROBINSON, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11478-11482

[10] DURATION OF CIRCULATING ANTIBODY AND IMMUNITY FOLLOWING INFECTION WITH EQUINE INFLUENZA-VIRUS [J].

HANNANT, D ;

MUMFORD, JA ;

JESSETT, DM .

VETERINARY RECORD, 1988, 122 (06) :125-128

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