Expression of Multiple Granzymes by Cytotoxic T Lymphocyte Implies that They Activate Diverse Apoptotic Pathways in Target Cells

被引：16

作者：

Zhou, Fang ^{[1
]}

机构：

[1] Univ Queensland, Diamantina Inst Canc Immunol & Metab Med, Princess Alexandra Hosp, Brisbane, Qld 4102, Australia

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2010年 / 29卷 / 01期

关键词：

granzyme; cytotoxic T lymphocytes; natural killer cells; apoptosis; caspase; perforin; GRANULE-MEDIATED APOPTOSIS; CYTOCHROME-C RELEASE; ASSEMBLY PROTEIN SET; FACTOR-II RECEPTOR; MANNOSE 6-PHOSPHATE RECEPTORS; B-INDUCED APOPTOSIS; CASPASE ACTIVATION; A-DEFICIENT; HUMAN NK; IN-VIVO;

D O I：

10.3109/08830180903247889

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Granzymes play a central role in cytotoxic T lymphocyte and natural killer cell-mediated apoptosis of target cell. Multiple granzymes are found in effector cells, and. their mechanisms to lead to apoptosis are different. Effector cells kill target cells via multiple pathways. At least three pathways of apoptosis mediated by granzymes have been found. Moreover, the abnormal activity of granzymes is related to many human diseases, such as autoimmune diseases. Granzymes play an important role in inflammatory response in vivo. The biological features and mechanisms of granzyme A, B, C, K, and M to induce cellular apoptosis are summarized.

引用

页码：38 / 55

页数：18

共 116 条

[1]

Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition [J].

Alimonti, JB ;

Shi, LF ;

Baijal, PK ;

Greenberg, AH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (10) :6974-6982

[2]

Granzyme B directly and efficiently cleaves several downstream caspase substrates: Implications for CTL-induced apoptosis [J].

Andrade, F ;

Roy, S ;

Nicholson, D ;

Thornberry, N ;

Rosen, A ;

Casciola-Rosen, L .

IMMUNITY, 1998, 8 (04) :451-460

[3]

Role of EndoG in development and cell injury [J].

Apostolov, E. O. ;

Wang, X. ;

Shah, S. V. ;

Basnakian, A. G. .

CELL DEATH AND DIFFERENTIATION, 2007, 14 (11) :1971-1974

[4]

Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization [J].

Arnoult, D ;

Gaume, B ;

Karbowski, M ;

Sharpe, JC ;

Cecconi, F ;

Youle, RJ .

EMBO JOURNAL, 2003, 22 (17) :4385-4399

[5]

Nephritogenic T tells use granzyme C as a cytotoxic mediator [J].

Bailey, NC ;

Kelly, CJ .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (09) :2302-2309

[6]

Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation [J].

Beresford, PJ ;

Xia, ZN ;

Greenberg, AH ;

Lieberman, J .

IMMUNITY, 1999, 10 (05) :585-594

[7]

Beresford PJ, 1998, J IMMUNOL, V161, P161

[8]

Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis? [J].

Blink, EJ ;

Trapani, JA ;

Jans, DA .

IMMUNOLOGY AND CELL BIOLOGY, 1999, 77 (03) :206-215

[9]

Granzyme K: a novel mediator in acute airway inflammation [J].

Bratke, K. ;

Klug, A. ;

Julius, P. ;

Kuepper, M. ;

Lommatzsch, M. ;

Sparmann, G. ;

Luttmann, W. ;

Virchow, J. C. .

THORAX, 2008, 63 (11) :1006-1011

[10]

Regulation of apoptosis by the redox state of cytochrome c [J].

Brown, Guy C. ;

Borutaite, Vilmante .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2008, 1777 (7-8) :877-881

← 1 2 3 4 5 6 7 8 9 10 →