Report of two novel chromosomal translocations in chronic lymphocytic leukemia

被引：3

作者：

Athanasiadou, A ^{[1
]}

Stamatopoulos, K

Tsompanakou, A

Foutsitsakis, D

Fassas, A

Anagnostopoulos, A

Tsezou, A

机构：

[1] G Papanicolaou Hosp, Dept Hematol, Thessaloniki 57010, Greece

[2] G Papanicolaou Hosp, BMT Unit, Thessaloniki 57010, Greece

[3] Univ Thessaly, Sch Med, Dept Biol & Genet, Larisa, Greece

来源：

LEUKEMIA & LYMPHOMA | 2005年 / 46卷 / 01期

关键词：

D O I：

10.1080/10428190400011591

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two novel chromosomal translocations were identified in 2 patients with chronic lymphocytic leukemia (CLL). Case 1: 60 year-old male, stage Rai 0/Binet A, with mutated immunoglobulin heavy (IgH) and lambda (Iglambda) light chain genes; karyotype: 46, XY, t(9;12)(q12;p11) [3]/ 46, XY [22]. Case 2: 56 year-old male, stage Rai 2/Binet B, with mutated IgH and unmutated Iglambda genes; karyotype: 46, XY, add(10)(q26), t(13;18)(q14;q21) [8]/ 46, XY [27]. Although both translocations are novel, the involved breakpoints (especially 13q14 and 18q21) have been reported to participate in various aberrations in CLL patients. Aberrations affecting bands 9q12 and 12p11, as in case 1, are generally rare.

引用

页码：133 / 136

页数：4

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