Epithelial mesenchymal transition Transcription Factor (TF): The structure, function and microRNA feedback loop

被引：31

作者：

Alidadiani, Neda ^{[1
]}

Ghaderi, Shahrooz ^{[1
]}

Dilaver, Nafi ^{[2
]}

Bakhshamin, Saina ^{[3
]}

Bayat, Mansour ^{[4
]}

机构：

[1] Rhur Univ Bochum, Dept Syst physiol, Bochum, Germany

[2] Swansea Univ, Coll Med, Swansea, W Glam, Wales

[3] Islamic Azad Univ, Young Res & Elite Club, Tehran, Iran

[4] Islamic Azad Univ, Sci & Res Branch, Dept Mycol, Tehran, Iran

来源：

GENE | 2018年 / 674卷

关键词：

EMT; Metastasis; miRNA; TF; TGF-BETA; REGULATORY NETWORKS; CELL INVASION; EMT; SNAIL; EXPRESSION; ZEB1; TWIST; PHOSPHORYLATION; PROGRESSION;

D O I：

10.1016/j.gene.2018.06.049

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epithelial to mesenchymal transition (EMT) is a phenomenon in which epithelial cells lose their cell to cell adhesion and detach from the base of the membrane. EMT is a fundamental process which occurs during tumor progression and metastasis. Cancer genomics is a complex network which involves a variety of factors such as transcription factors (TFs), coding genes and microRNAs (miRs). Both TFs and miRs are trans-regulatory elements that crosstalk. Due to a wide range of targets, TF-miR interaction provides a feedback or feedforward loop and cross-gene regulation consequently. In this review, we focused on the structure and function of two TF families involved in EMT, zinc finger and beta helix loop helix and p53. Subsequently we analyzed recent findings on TF-miR interaction in EMT.

引用

页码：115 / 120

页数：6

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