The mitochondrial inner membrane AAA metalloprotease family in metazoans

被引：28

作者：

Juhola, MK

Shah, ZH

Grivell, LA

Jacobs, HT ^{[1
]}

机构：

[1] Inst Med Technol, Tampere 33014, Finland

[2] Tampere Univ Hosp, Tampere 33014, Finland

[3] Univ Amsterdam, Mol Biol Sect, Swammerdam Inst Life Sci, NL-1098 SM Amsterdam, Netherlands

[4] Univ Glasgow, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

来源：

FEBS LETTERS | 2000年 / 481卷 / 02期

基金：

芬兰科学院;

关键词：

metalloprotease; AAA protein; chaperone; mitochondrion;

D O I：

10.1016/S0014-5793(00)01989-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three metalloproteases belonging to the AAA superfamily (Yme1p, Afg3p and Rca1p) are involved in protein turnover and respiratory chain complex assembly in the yeast inner mitochondrial membrane, Analysis of the completed genome sequences of Caenorhabditis elegans and Drosophila melanogaster indicates that this gene family typically comprises 3-4 members in metazoans, Phylogenetic analysis reveals three main branches represented, respectively, by Saccharomyces cerevisiae YME1, human SPG7 (paraplegin) and S, cerevisiae AFG3 and RCA1. mt-AAA metalloproteases are weak candidates for several previously studied Drosophila mutants. A full elucidation of the cellular and physiological roles of mt-AAA metalloproteases in metazoans will require the creation of targeted mutations, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V, All rights reserved.

引用

页码：91 / 95

页数：5

共 25 条

[1] The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease [J].