Functional deficits in basal ganglia of children with attention-deficit/hyperactivity disorder shown with functional magnetic resonance imaging relaxometry

被引:232
作者
Teicher, MH [1 ]
Anderson, CM
Polcari, A
Glod, CA
Maas, LC
Renshaw, PF
机构
[1] Harvard Univ, Sch Med, Consolidated Dept Psychiat, Boston, MA 02114 USA
[2] McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USA
[3] McLean Hosp, Brain Imaging Ctr, Belmont, MA 02178 USA
[4] Northeastern Univ, Sch Nursing, Boston, MA 02115 USA
[5] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA
关键词
D O I
10.1038/74737
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Attention-deficit/hyperactivity disorder is a highly heritable and prevalent neuropsychiatric disorder estimated to affect 6% of school-age children(1-3). Its clinical hallmarks are inattention, hyperactivity and impulsivity(4,5), which often respond substantially to treatment with methylphenidate or dextroamphetamine. Etiological theories suggest a deficit in corticostriatal circuits, particularly those components modulated by dopamine. We developed a new functional magnetic resonance imaging procedure (T2 relaxometry) to indirectly assess blood volume in the striatum (caudate and putamen) of boys 6-12 years of age in steady-state conditions. Boys with attention-deficit/hyperactivity disorder had higher T2 relaxation time measures in the putamen bilaterally than healthy control subjects. Relaxation times strongly correlated with the child's capacity to sit still and his accuracy in accomplishing a computerized attention task. Daily treatment with methylphenidate significantly changed the T2 relaxation times in the putamen of children with attention-deficit/hyperactivity disorder, although the magnitude and direction of the effect was strongly dependent on the child's unmedicated activity state. There was a similar but nonsignificant trend in the right caudate. T2 relaxation time measures in thalamus did not differ significantly between groups, and were not affected by methylphenidate. Attention-deficit/hyperactivity disorder symptoms may be closely tied to functional abnormalities in the putamen, which is mainly involved in the regulation of motor behavior.
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页码:470 / 473
页数:4
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