Clinical assessment of drug-induced disease

被引:63
作者
Gruchalla, RS [1 ]
机构
[1] Univ Texas, SW Med Ctr, Div Allergy & Immunol, Dallas, TX 75390 USA
关键词
D O I
10.1016/S0140-6736(00)02885-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Physicians are often confronted with patients who state that they are "allergic" to a drug or drugs. Knowing which medications can be prescribed safely is therefore difficult, and care of such patients frustrating. The goal of this review is to help physicians develop management plans for patients who present with drug-induced diseases'. It provides information that allows physicians to differentiate between reactions that are truly allergic in nature and those that are not immunologically mediated. Relevant information on medical history, physical findings, and laboratory tests that may be helpful in the assessment are discussed, and guidance is provided on when and if a drug may be safely readministered. Unfortunately, however, until we are able to better understand the mechanisms responsible for drug-induced reactions, our management tools will remain limited.
引用
收藏
页码:1505 / 1511
页数:7
相关论文
共 37 条
  • [1] ADKINSON N, 1998, ALLERGY PRINCIPLES P, V2, P1212
  • [2] [Anonymous], 1999, Ann Allergy Asthma Immunol, V83, P665
  • [3] Araujo O E, 1984, J Emerg Med, V2, P129, DOI 10.1016/0736-4679(84)90332-9
  • [4] ARKY R, 1999, PHYSICIANS DESK REFE
  • [5] The costs of adverse drug events in hospitalized patients
    Bates, DW
    Spell, N
    Cullen, DJ
    Burdick, E
    Laird, N
    Petersen, LA
    Small, SD
    Sweitzer, BJ
    Leape, LL
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (04): : 307 - 311
  • [6] CLINICAL AND LABORATORY MARKERS OF HYPERSENSITIVITY TO TRIMETHOPRIM-SULFAMETHOXAZOLE IN PATIENTS WITH PNEUMOCYSTIS-CARINII PNEUMONIA AND AIDS
    CARR, A
    SWANSON, C
    PENNY, R
    COOPER, DA
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (01) : 180 - 185
  • [7] Coombs RRA., 1975, Clinical Aspects of Immunology, P761
  • [8] Allergic reactions to drugs and biologic agents
    deShazo, RD
    Kemp, SF
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (22): : 1895 - 1906
  • [9] EISEN HN, 1959, CELLULAR HUMORAL ASP
  • [10] Sulfonamide-induced reactions in desensitized patients with AIDS - The role of covalent protein haptenation by sulfamethoxazole
    Gruchalla, RS
    Pesenko, RD
    Do, TT
    Skiest, DJ
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 101 (03) : 371 - 378