MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing

被引：1045

作者：

Ambros, V ^{[1
]}

机构：

[1] Dartmouth Coll, Sch Med, Dept Genet, Hanover, NH 03755 USA

来源：

CELL | 2003年 / 113卷 / 06期

关键词：

D O I：

10.1016/S0092-8674(03)00428-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drosophila geneticists have uncovered roles for microRNAs in the coordination of cell proliferation and cell death during development, and in stress resistance and fat metabolism. In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing.

引用

页码：673 / 676

页数：4

共 20 条

[1] The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs
Abrahante, JE
Daul, AL
Li, M
Volk, ML
Tennessen, JM
Miller, EA
Rougvie, AE
[J]. DEVELOPMENTAL CELL, 2003, 4 (05) : 625 - 637
[2] bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
Brennecke, J
Hipfner, DR
Stark, A
Russell, RB
Cohen, SM
[J]. CELL, 2003, 113 (01) : 25 - 36
[3] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
Calin, GA
Dumitru, CD
Shimizu, M
Bichi, R
Zupo, S
Noch, E
Aldler, H
Rattan, S
Keating, M
Rai, K
Rassenti, L
Kipps, T
Negrini, M
Bullrich, F
Croce, CM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) : 15524 - 15529
[4] CARRINGTON J, 2003, IN PRESS SCIENCE
[5] A Caenorhabditis elegans homologue of hunchback is required for late stages of development but not early embryonic patterning
Fay, DS
Stanley, HM
Han, M
Wood, WB
[J]. DEVELOPMENTAL BIOLOGY, 1999, 205 (02) : 240 - 253
[6] Hipfner DR, 2002, GENETICS, V161, P1527
[7] A microRNA in a multiple-turnover RNAi enzyme complex
Hutvágner, G
Zamore, PD
[J]. SCIENCE, 2002, 297 (5589) : 2056 - 2060
[8] Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny
Isshiki, T
Pearson, B
Holbrook, S
Doe, CQ
[J]. CELL, 2001, 106 (04) : 511 - 521
[9] THE C-ELEGANS HETEROCHRONIC GENE LIN-4 ENCODES SMALL RNAS WITH ANTISENSE COMPLEMENTARITY TO LIN-14
LEE, RC
FEINBAUM, RL
AMBROS, V
[J]. CELL, 1993, 75 (05) : 843 - 854
[10] The C-elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target
Lin, SY
Johnson, SM
Abraham, M
Vella, MC
Pasquinelli, A
Gamberi, C
Gottlieb, E
Slack, FJ
[J]. DEVELOPMENTAL CELL, 2003, 4 (05) : 639 - 650

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